You can design Avery labels that are 8 per sheet, 2x3 inches using the 22822 template in Avery Design & Print Online.
You can also use a template built into Microsoft Word or download an Avery 22822 template for Word, Photoshop, Illustrator, InDesign or Pages.
Here's some information on recommended printer settings.
If you want more information about a specific Avery label, search for the product number on avery.com.